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Pubertal androgen therapy in boys.

Alan D Rogol1

  • 1Department of Pediatrics, University of Virginia, USA. arogol@cstone.net

Pediatric Endocrinology Reviews : PER
|January 24, 2006
PubMed
Summary

Anabolic-androgenic steroids (AAS) are vital for male development and puberty. Androgen therapy aims to normalize testosterone levels for healthy growth, sexual maturation, and body composition in adolescents with delayed development or hypogonadism.

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Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Andrology

Background:

  • Anabolic-androgenic steroids (AAS) are crucial for male sexual differentiation, pubertal development, and overall health.
  • Androgen therapy is indicated for boys experiencing constitutional delay of growth and puberty (CDGP) or primary/secondary hypogonadism.
  • Maintaining physiological testosterone levels is essential throughout adolescent development and into adulthood.

Purpose of the Study:

  • To outline the principles and goals of androgen therapy in adolescent males.
  • To discuss the appropriate management of testosterone, dihydrotestosterone, and estradiol levels.
  • To evaluate the efficacy of various androgen preparations for adolescent development.

Main Methods:

  • Review of current literature and clinical guidelines on androgen therapy for adolescent males.
  • Analysis of different androgen administration routes (injectable, implantable, cutaneous) and their suitability.
  • Consideration of dosage adjustments required during the transition from prepubertal to adult stages.

Main Results:

  • Androgen therapy aims to restore serum testosterone (T) to normal ranges for each developmental stage.
  • Achieving normal levels of dihydrotestosterone and estradiol is also a key objective.
  • Cutaneous androgen preparations may pose challenges in delivering precise, low doses needed during adolescent development transitions.

Conclusions:

  • Androgen therapy is essential for achieving normal linear growth, including the adolescent growth spurt.
  • Successful therapy supports normal adolescent sexual development and attainment of appropriate body composition (lean mass, bone, fat distribution).
  • Psychological development appropriate for the adolescent's stage should also be facilitated by effective androgen normalization.

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