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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
[Antibacterial effect of nHA-PA66 in vitro]
Ling Ye1, Qin Su, Xue-dong Zhou
1Dept of Conservative Dentistry, West China College of Stomatology, Sichuan University, Chengdu.
Objective:
To evaluate the antibacterial activity of nHA-PA66 on the predominant bacteria of infected root canal in vitro.
Methods:
Agar diffusion method was the testing method. Porphyromonas gingivalis (P. gingivalis), Fusobacteria nucleatum (F. nucleatum) and Prevotalla intermedius (P. intermedius) were the tested bacteria. The powder and polymerized film of nHA-PA66 were the test mateials while the CCQ and filter paper as the control.
Results:
nHA-PA66's powder showed good antebacterial effect on the P. gingivalis and P. intermedius, its film was weaker. Both of them had no effect on F. nucleatum.
Conclusion:
nHA-PA66's antibacterial effect was not ideal, for better clinical results, some additives can be included.

