Related Experiment Video
Updated: Aug 13, 2026

06:46
Caudal-to-cranial Approach in Laparoscopic Right Hemicolectomy with Complete Mesocolon Excision and D3 Lymph Node Dissection
Published on: January 9, 2026
Caudal block complication in a patient with trisomy 13
1Department of Anesthesiology, Children's National Medical Center, Washington, DC, USA. icohen@cnmc.org
Paediatric Anaesthesia
|January 25, 2006
Summary
A caudal block complication occurred in a child with trisomy 13 due to spinal dysraphism. This case highlights risks of neuraxial anesthesia in patients with this genetic condition.
Area of Science:
- Pediatric Anesthesiology
- Clinical Case Report
- Medical Genetics
Background:
- Trisomy 13 (Patau syndrome) is a severe genetic disorder associated with multiple congenital anomalies.
- Neuraxial regional anesthesia, including caudal blocks, is a common technique in pediatric pain management.
- Patients with trisomy 13 may have undiagnosed spinal abnormalities that increase risks during these procedures.
Observation:
- A 4-year-old child with trisomy 13 experienced a complication during a planned caudal block.
- Positive aspiration of cerebrospinal fluid (CSF) led to the abortion of the procedure.
- Subsequent imaging revealed spinal dysraphism, including tethered cord and dural ectasia.
Findings:
- The case demonstrates a potential complication of caudal anesthesia in a child with trisomy 13.
- Undiagnosed spinal dysraphism, such as tethered cord, can lead to CSF leakage during neuraxial blocks.
- Congenital anomalies in trisomy 13 can increase the risk of adverse events with regional anesthesia.
Implications:
- Neuraxial regional anesthesia should be approached with extreme caution in pediatric patients with trisomy 13.
- Pre-procedure screening for spinal abnormalities is crucial in this population.
- Alternative anesthetic techniques may be safer for managing pain in children with trisomy 13 and spinal dysraphism.
Related Concept Videos
Meiosis I
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
Nondisjunction
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Nondisjunction
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
