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Urodynamic effects of propiverine hydrochloride in children with neurogenic detrusor overactivity: a prospective

Heinrich Schulte-Baukloh1, Gerd Mürtz, Thomas Henne

  • 1Department of Urology, St. Hedwig Hospital, Teaching Hospital of University Hospital Charité, Berlin, Germany. h.schulte-baukloh@alexius.de

BJU International
|January 25, 2006
PubMed

Insights

Propiverine hydrochloride effectively treats neurogenic detrusor overactivity (NDO) in children, improving bladder capacity and reducing incontinence. This medication is well-tolerated, offering a favorable alternative to oxybutynin.

Area of Science:

  • Pediatric Urology
  • Neurogenic Bladder Management
  • Pharmacological Interventions

Background:

  • Neurogenic detrusor overactivity (NDO) affects children with neurological conditions, leading to bladder dysfunction.
  • Current treatments, like oxybutynin, have limitations in efficacy and tolerability.

Purpose of the Study:

  • To prospectively assess the efficacy and tolerability of propiverine hydrochloride in pediatric patients with NDO.
  • To compare propiverine's effects on urodynamic parameters and incontinence with baseline measurements.

Main Methods:

  • Twenty children with NDO due to upper motor neurone lesions were enrolled.
  • Urodynamic parameters (RV, MDP, MCBC, BC) and incontinence scores were measured before and after a 3-6 month propiverine regimen.
  • Children received twice-daily propiverine hydrochloride, with some receiving higher doses than recommended.

Main Results:

  • Propiverine significantly increased reflex volume (RV) and maximum cystometric bladder capacity (MCBC).
  • Maximum detrusor pressure (MDP) decreased, and bladder compliance (BC) improved significantly with treatment.
  • Incontinence scores improved, and propiverine was well-tolerated, even at higher doses.

Conclusions:

  • Propiverine hydrochloride demonstrates significant efficacy in improving urodynamic parameters and reducing incontinence in children with NDO.
  • The drug is well-tolerated, with a favorable profile even when higher doses are required.
  • Propiverine represents a valuable and well-tolerated alternative to oxybutynin for managing pediatric NDO.
Abstract

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