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Related Experiment Videos

Collection of hyperconcentrated platelets with Trima Accel.

J Ringwald1, T Duerler, O Frankow

  • 1Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany. juergen.ringwald@trans.imed.uni-erlangen.de

Vox Sanguinis
|January 25, 2006
PubMed
Summary

The Trima Accel device can collect hyperconcentrated platelet (PLT) products at 5000 x 10(3) PLTs/microl, though productivity improvements are needed. This apheresis system shows potential for high-concentration PLT collection, enhancing transfusion medicine.

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Area of Science:

  • Apheresis technology
  • Transfusion medicine
  • Hematology

Background:

  • Reducing plasma content in single-donor platelet (PLT) concentrates requires collecting platelets at very high concentrations.
  • The Trima Accel (TA) apheresis system is validated for PLT collection up to 4000 x 10(3) PLTs/microl.

Purpose of the Study:

  • To evaluate the performance of the Trima Accel (TA) system for collecting platelet concentrates at a target concentration of 5000 x 10(3) PLTs/microl.
  • To assess collection efficiency, collection rate, and by-product quality at hyperconcentrated settings.

Main Methods:

  • Twenty blood donors underwent apheresis using the Trima Accel system twice.
  • Donors received collections for either hyperconcentrated (target 5000 x 10(3) PLTs/microl) or standard (target 1200 x 10(3) PLTs/microl) single-donor platelet concentrates.

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  • Analysis included collection efficiency, rate, and by-plasma quality.

    • Main Results:

    • Hyperconcentrated units averaged 2.56 x 10(11) PLTs at 4518 x 10(3) PLTs/microl in 45 minutes, with 47.5% collection efficiency.
    • Standard units averaged 3.39 x 10(11) PLTs at 1374 x 10(3) PLTs/microl in 39 minutes, with 70.7% collection efficiency.
    • The collected by-plasma demonstrated high cell purity and satisfactory clotting factor recovery.

    Conclusions:

    • The Trima Accel system is suitable for collecting platelet concentrates at very high concentrations.
    • Further improvements in productivity are desirable to optimize collection above the current validated limit.
    • This study supports the potential of TA for advanced apheresis applications in transfusion support.