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Dual effects of calcium on ATP-sensitive potassium channels of frog skeletal muscle
P Krippeit-Drews1, U Lönnendonker
1I. Physiologisches Institut der Universität des Saarlands, Homburg, Germany.
Biochimica Et Biophysica Acta
|July 8, 1992
Abstract:
The block of ATP-sensitive K+ channels by ATP were studied in inside-out patches of frog toe muscles. Seal formation within Ca(2+)-free Ringer induces many open channels which can be irreversibly blocked by subsequent addition of Ca2+. However, such Ca(2+)-blocked and ATP-blocked channels can be influenced by the addition of ATP and Ca2+: the block by ATP is partially but irreversibly cancelled.