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Updated: Aug 13, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients
A Martínez1, V de las Heras, A Mas Fontao
1Clinical Immunology Department, Hospital Clinico San Carlos, C/ Martín Lagos s/n 28040 Madrid, Spain. alfmdoncel@terra.es
Abstract:
Interferon-beta is a biological treatment widely used in multiple sclerosis (MS). However, not every patient responds equally well to this therapy. In this study, our aim was to evaluate the influence of a dinucleotide microsatellite located in the first intron of the interferon-gamma gene on relapse eradication in a group of interferon-beta-treated patients. Our results show a very different allelic distribution when patients with relapses were compared with relapse-free patients.