Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats.

I Ikeda1, Y Imasato, E Sasaki

  • 1Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.

Biochimica Et Biophysica Acta
|July 29, 1992
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia.

Rhinology·2024
Same author

Comment on "Ectopic thymic carcinoma of the parotid gland".

International journal of oral and maxillofacial surgery·2024
Same author

Amiodarone-induced pneumonitis.

QJM : monthly journal of the Association of Physicians·2021
Same author

Triply bridged dinuclear ruthenium complexes bearing alkylbis(2-pyridylmethyl)amine in the mixed-valence state of Ru(ii)-Ru(iii).

Dalton transactions (Cambridge, England : 2003)·2018
Same author

Peracute Bacterial Meningitis due to Infection with Klebsiella pneumoniae in Captive-bred Ruffed Lemurs (Varecia variegate).

Journal of comparative pathology·2017
Same author

Pharmacological Properties of Propiverine Contribute to Improving Lower Urinary Tract Dysfunctions in Rats with Spinal Cord Injuries.

Drug research·2016

Tea catechins, especially gallate esters like EGCG, significantly reduce cholesterol absorption by decreasing its solubility in micelles. This explains the cholesterol-lowering effects of tea consumption.

Area of Science:

  • Biochemistry
  • Nutrition Science
  • Gastroenterology

Background:

  • Dietary cholesterol absorption is a key factor in maintaining cholesterol homeostasis.
  • Tea catechins are known for their potential health benefits, including antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To investigate the effect of tea catechins on lymphatic cholesterol and triacylglycerol absorption in rats.
  • To elucidate the mechanism by which tea catechins influence cholesterol absorption in vitro.

Main Methods:

  • In vivo study using rats with a cannulated thoracic duct to measure lymphatic absorption.
  • In vitro study assessing the effect of tea catechins on cholesterol micellar solubility using bile salt micelles.

Main Results:

Related Experiment Videos

  • Mixtures of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) significantly reduced lymphatic cholesterol absorption more than EC and EGC.
  • Tea catechins, particularly gallate esters, dose-dependently precipitated cholesterol from mixed bile salt micelles.
  • EGCG demonstrated a stronger cholesterol-precipitating effect than ECG, and both were more effective than their non-gallate counterparts.

Conclusions:

  • Tea catechins, especially EGCG and ECG, inhibit intestinal cholesterol absorption by reducing cholesterol's micellar solubility.
  • This mechanism provides a scientific basis for the observed hypocholesterolemic effects of tea consumption.