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[Rapid diagnosis of Chlamydia trachomatis using a DNA probe in a population with low risk of infection]
M Rosales1, V Domínguez, I Bonacho
1Servicio de Medicina Preventiva y Salud Pública, Hospital Juan Canalejo, La Coruña.
Background:
To assess the efficacy of a newer diagnostic technique for Chlamydia trachomatis and its usefulness as screening method in populations at low-risk for Chlamydia trachomatis infection.
Methods:
Open comparative trial between the EIA technique (Abbott Laboratories) and DNA gene probe (Gen Probe Diagnostic). A total of 1683 individuals (1630 women and 53 men) were screened with the two different techniques using samples obtained simultaneously.
Results:
Among women, 66 give a positive result either by one or another technique. The prevalence was 4.04%. Sensitivity of DNA probe when compared with EIA assay was 64% and specificity was 98.9%.
Conclusions:
The DNA probe technique is faster than actual techniques and easy to do without major laboratory equipment. However, its price is high and its sensitivity poor in low-risk populations.