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Intravenous immunoglobulin for immunomodulation of systemic lupus erythematosus

Yaniv Sherer1, Yehuda Shoenfeld

  • 1Department of Medicine 'B' & Center for Autoimmune Diseases, Sheba Medical Center Tel-Hashomer, Israel.

Autoimmunity Reviews
|January 25, 2006
PubMed

Intravenous immunoglobulin (IVIg) is used for replacement therapy in immunodeficiency states and for immunomodulation of various autoimmune diseases. Several case reports and series support a beneficial role of IVIg in systemic lupus erythematosus (SLE), both as salvage immunotherapy and in control of disease activity in general and amelioration of classical disease manifestations. Further, lupus nephritis can also be treated usually successfully with IVIg. A few questions remain unanswered as to the appropriate therapeutic dosage and the clinical manifestations that can be best treated with IVIg.

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