A review of the effects and mechanisms of polyphenolics in cancer

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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Sailendra N Nichenametla1, Todd G Taruscio, Danny L Barney

  • 1Department of Food Science and Toxicology, University of Idaho, Moscow, ID 83844-2201, USA.

Critical Reviews in Food Science and Nutrition
|January 25, 2006
PubMed

Insights

Dietary polyphenols from fruits and vegetables show potential cancer chemopreventative activity. This review compiles evidence on their effects, mechanisms, and interactions, highlighting both protective and potentially harmful outcomes.

Area of Science:

  • Nutritional Science
  • Oncology
  • Biochemistry

Background:

  • Bioactive polyphenolic compounds are abundant in fruits and vegetables.
  • These compounds include phenolic acids, anthocyanins, catechins, stilbenes, and flavonoids.
  • Their role in cancer prevention and progression is an area of active research.

Purpose of the Study:

  • To comprehensively review the effects of dietary polyphenols on cancer.
  • To compile existing research on polyphenol occurrence, bioavailability, and anticancer mechanisms.
  • To evaluate both positive and negative impacts of polyphenols on cancer development.

Main Methods:

  • Systematic literature review of major studies on polyphenols and cancer.
  • Compilation of data on in vitro and in vivo evidence.
  • Analysis of proposed molecular mechanisms of action.

Main Results:

  • Most studies indicate chemopreventative activity of polyphenols.
  • Some research suggests potential cancer-inducing or neutral effects.
  • Common mechanisms involve modulation of cellular differentiation, proliferation, and apoptosis.

Conclusions:

  • Dietary polyphenols exhibit complex interactions with cancer development.
  • Further research is needed to elucidate mechanisms and optimize therapeutic potential.
  • Understanding these interactions is crucial for dietary cancer prevention strategies.

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