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Lymph node histology simulating T-cell lymphoma in adult-onset Still's disease
L J Reichert1, J J Keuning, M van Beek
1Department of Internal Medicine, University Hospital St. Radboud, Nijmegen, The Netherlands.
Annals of Hematology
|July 1, 1992
Abstract:
A patient with adult-onset Still's disease (AOSD) underwent lymph node biopsy as part of initial evaluation for fever of unknown origin. The lymph node histology showed a massive, diffuse immunoblastic hyperplasia, simulating T-cell lymphoma. This nodal histology differs from rheumatoid arthritis, where mostly a follicular B-cell reaction predominates. Evaluating fever of unknown origin when one is unacquainted with this massive immunoblastic hyperplasia can lead to the wrong diagnosis of T-cell lymphoma in patients with AOSD.