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Reversible bone marrow aplasia induced by naproxen.
1Division of Hematology, Medical College of Georgia, Augusta 30912-3125.
Annals of Hematology
|July 1, 1992
Summary
Naproxen use can cause reversible bone marrow aplasia, leading to severe pancytopenia. Discontinuing the drug resulted in full recovery of bone marrow function in a unique case study.
Area of Science:
- Hematology
- Pharmacology
- Toxicology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Drug-induced bone marrow aplasia is a rare but serious adverse effect.
- Naproxen is a common NSAID with a well-established safety profile.
Observation:
- A 71-year-old woman developed severe pancytopenia after 8 weeks of naproxen treatment.
- Bone marrow biopsy revealed marked hypocellularity, consistent with aplastic anemia.
- No other potential causative agents or underlying conditions were identified.
Findings:
- Naproxen was identified as the likely cause of reversible bone marrow aplasia.
- Discontinuation of naproxen led to complete hematologic and bone marrow recovery.
- This case highlights a rare adverse reaction to a commonly used medication.
Implications:
- Clinicians should consider naproxen as a potential cause of pancytopenia in patients.
- Early recognition and drug withdrawal are crucial for favorable outcomes.
- Further research into the mechanisms of NSAID-induced bone marrow toxicity is warranted.