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Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization

Albert C Lardo1, Marco A S Cordeiro, Caterina Silva

  • 1Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. al@jhmi.edu

Circulation
|January 25, 2006
PubMed

Insights

Contrast-enhanced multidetector computed tomography (MDCT) accurately quantifies myocardial infarction size and microvascular obstruction. This imaging technique aids in assessing cardiovascular disease progression and prognosis after heart attacks.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Myocardial Infarction Research

Background:

  • Distinguishing viable from nonviable myocardium is crucial for prognosis post-myocardial infarction.
  • Contrast-enhanced multidetector computed tomography (MDCT) offers potential for quantifying myocardial damage.

Purpose of the Study:

  • To validate the accuracy of contrast-enhanced MDCT in quantifying myocardial necrosis, microvascular obstruction, and chronic scar after myocardial infarction.

Main Methods:

  • Ten dogs and seven pigs underwent coronary artery occlusion and reperfusion.
  • Contrast-enhanced MDCT was performed before occlusion and at intervals post-reperfusion.
  • MDCT findings were compared with postmortem myocardial staining and blood flow measurements.

Main Results:

  • MDCT accurately identified acute and chronic infarcts by hyperenhancement and microvascular obstruction by hypoenhancement.
  • MDCT infarct volumes closely correlated with triphenyltetrazolium chloride staining.
  • MDCT accurately reflected infarct morphology, transmural extent, and correlated with reduced blood flow.

Conclusions:

  • Contrast-enhanced MDCT accurately determines and quantifies the spatial extent of acute and healed myocardial infarction.
  • Combined with MDCT coronary angiography, this technique has significant implications for cardiovascular disease assessment.
Abstract

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