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Updated: Aug 13, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
Published on: October 17, 2015
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments
Kulandaivelu S Vetrivel1, Gopal Thinakaran
1Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA.
Abstract:
Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of Abeta as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of beta- and gamma-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.
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