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Updated: Aug 13, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Revolution and evolution: 30 years of ileoanal pouch surgery
Simon P Bach1, Neil J M Mortensen
1Nuffield Department of Surgery, University of Oxford and the Department of Colorectal Surgery, John Radcliffe Hospital, Oxford, United Kingdom. simon.bach@nds.ox.ac.uk
Abstract:
Ileal pouch-anal anastomosis (IPAA) has become the standard of care for the 25% of patients with ulcerative colitis who ultimately require colectomy. IPAA is favored by patients because it avoids the necessity for a long-term stoma. This review examines how 3 decades of experience with IPAA has molded current practice, highlighting 5- and 10-year follow-up of large series to determine durability and functional performance, in addition to causes of failure and the management of complications.
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