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A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
Published on: May 21, 2010
Antimony-induced cerebellar ataxia
Eltahir Awad G Khalil1, Ammar E Ahmed, Ahmed M Musa
1Department of Clinical Pathology and Immunology. Institute of Endemic Diseases, University of Khartoum, PO Box 45235, Khartoum, Sudan. eltahirk@iend.org
Abstract:
Visceral leishmaniasis VL, caused by Leishmania donovani is endemic over several parts of Sudan. The disease is fatal if not treated. Although sodium stibogluconate Pentostam, a pentavalent antimonial is not free from toxicity, it has been in use for treatment of VL for the last 50 years. Like other infectious diseases, neurological manifestations of VL and sodium stibogluconate have been documented. In this report, we present 2 cases of cerebellar ataxia most likely induced by Pentostam, and explain the probable cause.
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