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Beta1-subunit modulates the Nav1.4 sodium channel by changing the surface charge

Loretta Ferrera1, Oscar Moran

  • 1Istituto di Biofisica, CNR, Via De Marini 6, Genova, Italy.

Experimental Brain Research
|January 25, 2006
PubMed
Summary

The beta1-subunit of voltage-gated sodium channels modulates neuronal excitability by increasing negative surface charges. This affects how calcium ions influence sodium channel gating.

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