Related Experiment Video
Updated: Aug 13, 2026
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
[Hydration of patients treated with cisplatin: practical investigation and establishment of a protocol]
Guillaume Saint-Lorant1, Jeannick Madelaine, Marie-Pierre Galais
1Pharmacie Centrale, CHU de Caen, Caen, France. guillaume.saint-lorant@wanadoo.fr
Background:
Administration of cisplatin requires hyperhydration of the patient to prevent nephrotoxic effects of this molecule.
Materials And Methods:
A survey done in different hospitals - university hospitals, general hospitals and cancer institutes--has shown a large variability in the hydration protocols. A multidisciplinary group was set up in our university hospital comprising oncologists, nephrologists and pharmacists. This group has developed a consensual local protocol from a bibliographic analysis (Medline) and from the personal experience of each member.
Conclusion:
This protocol was approved by our hospital's Committee of Drugs and Medical Devices.
