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[Allergic reactions to paracetamol].

Riadh Daghfous1, Sihem El Aidli, Anis Jday

  • 1Centre National de Pharmacovigilance, Hôpital Charles Nicolle, Tunis, Tunisie. Riadh.Daghfous@fmt.rnu.tn

Therapie
|January 26, 2006
PubMed
Summary

Allergy to paracetamol is rare but not uncommon, with previous allergies to paracetamol or aspirin increasing risk. Most allergic reactions resolved favorably, but contraindication is advised for high-risk patients.

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Area of Science:

  • Pharmacovigilance
  • Clinical Allergy
  • Drug Safety

Context:

  • Paracetamol (acetaminophen) is a widely used analgesic and antipyretic.
  • Allergic reactions to paracetamol are reported but often considered moderate.
  • Understanding risk factors and clinical presentation is crucial for patient safety.

Purpose:

  • To retrospectively analyze cases of allergic reactions to paracetamol.
  • To identify potential risk factors and clinical manifestations of paracetamol allergy.
  • To evaluate the outcomes and management of paracetamol-induced hypersensitivity.

Summary:

  • A study reviewed 119 cases of paracetamol allergy reported between 1990-2000.
  • Key findings include a history of allergy/atopy, co-administration with other drugs, and varied dermatological reactions (urticaria, macular/pustular eruptions, fixed drug eruption).

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  • Serious reactions like Lyell syndrome and anaphylactic shock occurred, but all cases resolved favorably with definitive contraindication for high-imputability patients.

    • Impact:

    • Highlights that paracetamol allergy, while rare, is a significant concern.
    • Identifies personal history of paracetamol or aspirin allergy as key risk factors.
    • Emphasizes the importance of pharmacovigilance in detecting and managing adverse drug reactions.