Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The haloperidol story.

Bernard Granger¹, Simona Albu

¹Service de Psychiatrie d'Adultes, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Université Paris 5, Paris, France. granger@necker.fr

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists

|January 26, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Post-procedural infection risk following laser vaginal rejuvenation: clinical experience from a single center.

Germs·2025

Same author

Laser labiaplasty and vaginal rejuvenation: how to reach zero post-operative infections. An expert opinion and short narrative review on protocols, safety and outcome.

Germs·2025

Same author

Dynamic Functional Connectivity in Adolescence-Onset Major Depression: Relationships With Severity and Symptom Dimensions.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2021

Same author

Lower midbrain dopamine transporter availability in depressed patients: Report from high-resolution PET imaging.

Journal of affective disorders·2019

Same author

Tailored-Dose Baclofen in the Management of Alcoholism: A Retrospective Study of 144 Outpatients Followed for 3 Years in a French General Practice.

Frontiers in psychiatry·2018

Same author

Population pharmacokinetics of oral baclofen at steady-state in alcoholic-dependent adult patients.

Fundamental & clinical pharmacology·2017

Haloperidol, a potent antipsychotic, was synthesized in 1958. Clinical studies confirmed its effectiveness against delusions and hallucinations, leading to widespread use before newer medications emerged.

Area of Science:

Psychopharmacology
Neuroscience
Medicinal Chemistry

Background:

Haloperidol, a first-generation antipsychotic, belongs to the butyrophenone class.
Developed at Janssen Laboratories in 1958, its synthesis marked a significant advancement in psychiatric pharmacotherapy.

Observation:

Initial animal studies indicated haloperidol possessed a more potent action than chlorpromazine.
Early human trials at Liege hospital demonstrated significant efficacy in treating positive psychotic symptoms.

Findings:

Haloperidol was confirmed to be highly effective against delusions and hallucinations.
Despite initial challenges in the USA, it became a widely used treatment in Western countries for decades.

Implications:

Related Experiment Videos

The development of haloperidol represented a major step forward in managing psychosis.
Its long-term use highlights its historical importance in psychiatric treatment prior to the advent of atypical antipsychotics.