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Related Experiment Videos

Primary ciliary dyskinesia in the dog.

D F Edwards1, C S Patton, J R Kennedy

  • 1Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville.

Problems in Veterinary Medicine
|June 1, 1992
PubMed
Summary

Congenital ciliary dysfunction in dogs causes impaired mucociliary clearance, leading to respiratory infections and infertility. Diagnosis involves assessing ciliary function and ultrastructure, with treatment focusing on supportive care.

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Area of Science:

  • Veterinary Medicine
  • Genetics
  • Cell Biology

Background:

  • Congenital ciliary dysfunction is a genetic disorder affecting dogs.
  • It results in immotile or dyskinetic cilia and sperm flagella, impacting multiple organ systems.
  • Clinical signs include respiratory issues and male infertility.

Purpose of the Study:

  • To describe the clinical manifestations, diagnosis, and potential inheritance of congenital ciliary dysfunction in dogs.
  • To highlight the importance of mucociliary clearance assessment and ultrastructural analysis.

Main Methods:

  • Clinical observation of affected dogs.
  • Assessment of mucociliary clearance (nasal, tracheal).
  • Ultrastructural analysis of cilia and sperm flagella.
  • In vitro analysis of ciliary activity.
  • Differential diagnosis to rule out other conditions.

Main Results:

  • Impaired mucociliary clearance leads to chronic nasal discharge, sneezing, coughing, rhinosinusitis, and bronchopneumonia.
  • Variable features include hypoplastic nasal sinuses, secretory otitis media, male infertility, hydrocephalus, and situs inversus.
  • Diagnosis confirmed by absent mucociliary clearance and specific ultrastructural ciliary lesions or functional tests.
  • Autosomal recessive inheritance is probable, but dominant mutations are possible.

Conclusions:

  • Congenital ciliary dysfunction is a significant cause of respiratory and reproductive problems in dogs.
  • Accurate diagnosis requires a combination of clinical signs, functional tests, and ultrastructural examination.
  • Supportive care can prolong survival, but potential sequelae like cor pulmonale and amyloidosis exist.

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