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Updated: Jul 29, 2026

Programmed Electrical Stimulation in Mice
Published on: May 27, 2010
[Value and limitations of programmed ventricular stimulation]
A Leenhardt1, F Extramiana, P Milliez
1Service de cardiologie, hôpital Lariboisière,2, rue Ambroise Paré, 75475 Paris. antoine.leenhardt@lrb.ap-hop-paris.fr
Programmed ventricular stimulation aids in diagnosing complex cardiac arrhythmias when standard ECGs are insufficient. While its use for rhythm stratification has decreased, it remains valuable for prognosis in specific conditions and expanding therapeutic applications.
Area of Science:
- Cardiology
- Electrophysiology
Context:
- Electrocardiography (ECG) and prolonged ECG monitoring are standard for diagnosing most cardiac arrhythmias and guiding treatment.
- Endocavitary electrophysiological investigations are sometimes necessary for uncertain diagnoses, enhanced prognostic information, or planning interventional procedures like endocavitary ablation.
Purpose:
- To summarize the clinical utility and limitations of programmed ventricular stimulation (PVS).
- To evaluate the evolving role of PVS in cardiac arrhythmia management.
Summary:
- PVS is less frequently used for rhythm stratification due to more reliable parameters like left ventricular ejection fraction.
- However, PVS retains prognostic value in specific conditions such as arrhythmogenic right ventricular dysplasia, Brugada syndrome, and post-operative Tetralogy of Fallot.
- Strict adherence to established protocols is crucial for the validity of diagnostic and therapeutic recommendations derived from PVS studies.
Impact:
- The indications for PVS are expanding in the therapeutic domain, driven by advancements in 3D mapping and catheter guidance systems.
- These technological developments are expected to broaden the scope of endocavitary ablation procedures.
- PVS continues to be an important tool for risk stratification and guiding interventions in select cardiac arrhythmia patients.
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