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Updated: Aug 13, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
Published on: February 20, 2021
[Role of cytokines and pathogen associated molecular pattern receptors in sepsis]
Piotr Kłuciński1, Gayane Martirosian
1Katedra i Zakład Mikrobiologii Lekarskiej Slaskiej Akademii Medycznej w Katowicach.
Abstract:
Sepsis is life-treating state caused by overwhelming inflammatory response to infection accompanied by disregulation of non-specific immunity mechanisms. In this review we discussed influence of Gram-positive and Gram-negative bacterial virulence factors, cytokines as well as pathogen associated molecular pattern receptors (TLR-toll like receptors, peptydoglican recognition proteins, nucleotide binding oligomerization domains, triggering receptor expressed on myeloid cells-1) on the development and course of sepsis.
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