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[The genetic determinism of polygenic diseases]
Bulletin De L'Academie Nationale De Medecine
|January 26, 2006
Abstract:
Progress in molecular biology has opened the way to identifying genes involved in predisposition to multigene diseases. The two methods currently used for this purpose--analysis of candidate genes and systematic genomic screening--have given interesting but only very partial results. The problem is complicated by the large number of genes involved, their low penetrance, and linkage disequilibrium.
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