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Updated: Aug 13, 2026
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Sézary syndrome associated with granulomatous lesions during treatment with bexarotene
A Ruiz-de-Casas1, A Carrizosa-Esquivel, A Herrera-Saval
1Department of Dermatology, Virgen Macarena University Hospital, Seville, Spain. aruizdecasas@aedv.es
Abstract:
Sézary syndrome (SS) is a leukaemic variant of cutaneous T-cell lymphoma (CTCL). We report a patient with SS who developed granulomatous lesions. These lesions broke out during treatment with bexarotene when the disease had appeared to stabilize. After a partial clinical remission the disease showed rapid progression and finally led to the patient's death. This contradicts the initial assessment, which considered the granulomatous inflammation as a good prognostic factor in CTCL.
