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Updated: Aug 13, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
Preeclampsia: the death of Goliath
1Women's Health Associates, 101 Prospect Street, Suite 202, Lakewood, NJ 08701, USA. bfeinberg@sbhcs.com
Abstract:
In this review, a novel and unifying pathophysiologic mechanism of preeclampsia is presented whereby a minimal excess of placental immune complex production versus removal causes a proinflammatory autoamplification cascade of trophoblast apoptosis/necrosis and oxidative stress, culminating in clinical preeclampsia. This concept immediately leads to a plethora of new and robust therapeutic strategies.
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