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Pharmacokinetics of liposomal amphotericin B during extracorporeal albumin dialysis

Helene Vogelsinger1, Michael Joannidis, Jordan Kountchev

  • 1Clinical Pharmacokinetics Unit, Innsbruck Medical School, Innsbruck, Austria.

Artificial Organs
|January 26, 2006
PubMed

Insights

Albumin dialysis did not significantly alter liposomal amphotericin B levels in a patient with invasive mycosis. Plasma concentrations of liposomal amphotericin B remained higher than liberated forms during treatment.

Area of Science:

  • Pharmacology
  • Nephrology
  • Oncology

Background:

  • Extracorporeal blood purification techniques can unpredictably affect antimicrobial pharmacokinetics.
  • The impact of albumin dialysis on lipid-formulated drugs, specifically liposomal amphotericin B (AMB), remains unstudied.

Observation:

  • Plasma concentrations of liposomal and liberated AMB were measured in a patient undergoing albumin dialysis for cholestatic liver failure post-bone marrow transplant.
  • The patient received liposomal AMB for a suspected invasive fungal infection.

Findings:

  • Albumin dialysis did not lead to excessive elimination of AMB.
  • Plasma levels of liposomal AMB were consistently higher than liberated AMB.
  • Pharmacokinetic data were similar to those observed in patients undergoing hemofiltration or without extracorporeal blood purification.

Implications:

  • Albumin dialysis appears to be a safe method for AMB administration in patients requiring both treatments.
  • Further research is warranted to confirm these findings in a larger patient cohort.
  • Understanding drug-specific interactions with extracorporeal therapies is crucial for optimizing patient care.

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