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Von Willebrand disease.

Andra H James1

  • 1Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA. andra.james@duke.edu

Obstetrical & Gynecological Survey
|January 26, 2006
PubMed
Summary

Von Willebrand disease (VWD) is a common inherited bleeding disorder. Women with VWD often experience heavy menstrual bleeding and increased risks during pregnancy, requiring specialized care.

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Area of Science:

  • Hematology
  • Obstetrics & Gynecology

Background:

  • Von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder, stemming from von Willebrand factor (VWF) deficiency.
  • VWD affects up to 1.3% of the population, with significant implications for women's reproductive health.

Purpose of the Study:

  • To review the obstetric and gynecologic manifestations of VWD in women.
  • To highlight the increased risks of bleeding-related conditions in women with VWD.
  • To discuss available management and prophylaxis strategies.

Main Methods:

  • Literature review of VWD and its impact on women's health.
  • Analysis of reported symptoms, complications, and treatment options.

Main Results:

  • Menorrhagia is a primary symptom in 32-100% of women with VWD.
  • Increased risks include hemorrhagic ovarian cysts, endometriosis, fibroids, and postpartum hemorrhage.
  • Pregnancy in women with VWD carries higher risks of miscarriage and bleeding complications.

Conclusions:

  • Women with VWD face disproportionately higher risks for various gynecologic and obstetric bleeding complications.
  • Effective management strategies, including prophylaxis, are crucial for mitigating these risks.
  • Early recognition and management are essential for improving outcomes in affected women.

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