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Updated: Aug 8, 2026

Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices
Published on: October 29, 2012
Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels
1Department of Cell Biology and Anatomy, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Abstract:
Neuronal nicotinic acetylcholine receptors are oligomeric protein complexes whose component subunits are each encoded by a family of homologous genes. The current challenge is to determine the functional contributions of the related subunits to the receptor-linked ion channels they compose and to uncover the physiological impact of the distinct channel classes expressed in vivo. In the past year, new approaches to the analysis of these receptors have yielded important insights into their stoichiometry, pharmacology and functional properties.
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