Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal Ca2+ signalling takes the local route.

G J Augustine1, E Neher

  • 1Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.

Current Opinion in Neurobiology
|June 1, 1992
PubMed
Summary

Fast, large, and localized rises in intracellular calcium (Ca2+) concentration occur in neurons. This confirms theoretical predictions of spatial compartmentalization for rapid neuronal signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors.

Genes, brain, and behavior·2018
Same author

Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.

Molecular psychiatry·2016
Same author

Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability.

Molecular plant·2015
Same author

Introduction: regulated exocytosis.

Cell calcium·2012
Same author

Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release.

Proceedings of the National Academy of Sciences of the United States of America·2008
Same author

Kinetics of both synchronous and asynchronous quantal release during trains of action potential-evoked EPSCs at the rat calyx of Held.

The Journal of physiology·2007

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Biophysics

Background:

  • Neuronal signaling relies on precise control of ion concentrations.
  • Calcium ions (Ca2+) play a critical role in various cellular processes, including neurotransmitter release and gene expression.
  • Understanding the spatial dynamics of Ca2+ is crucial for deciphering neuronal function.

Purpose of the Study:

  • To investigate the occurrence and characteristics of rapid, localized increases in intracellular Ca2+ concentration in neurons.
  • To confirm theoretical predictions regarding spatial compartmentalization of Ca2+ signaling.
  • To document a signaling mechanism potentially involved in rapid and local signal processing.

Main Methods:

  • Experimental validation of theoretical models.
  • Utilizing advanced techniques to measure rapid and localized changes in intracellular Ca2+ concentration.
  • Analysis of spatial and temporal dynamics of Ca2+ signaling events.

Main Results:

  • Experimental evidence confirms the occurrence of fast, large, and highly localized rises in intracellular Ca2+ concentration in neurons.
  • These findings support theoretical predictions of acute spatial compartmentalization of Ca2+ signaling.
  • The study documents a signaling mechanism relevant for scenarios requiring rapid and local signal processing.

Conclusions:

  • Fast, localized Ca2+ signals are a reality in neuronal function.
  • Spatial compartmentalization of Ca2+ signaling is a key feature in neurons.
  • Further research is needed to overcome measurement challenges and fully understand these signaling events.

Related Experiment Videos