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Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation
Thota Ganesh1, Andrew Norris, Shubhada Sharma
1Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Bioorganic & Medicinal Chemistry
|January 26, 2006
Abstract:
A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself.
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