Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning
View abstract on PubMed
Summary
This summary is machine-generated.Myocardial injury is common in carbon monoxide (CO) poisoning patients and significantly increases long-term mortality risk. Early detection and management of cardiac effects are crucial for improving patient outcomes after CO exposure.
Area Of Science
- Toxicology
- Cardiology
- Environmental Health
Background
- Carbon monoxide (CO) poisoning is a leading cause of toxicological death.
- Myocardial injury is a frequent complication of moderate to severe CO poisoning.
- Long-term outcomes for patients with CO-induced myocardial injury are not well-established.
Purpose Of The Study
- To investigate the association between myocardial injury and long-term mortality.
- To assess the prognostic significance of cardiac troponin I and creatine kinase-MB levels.
- To evaluate electrocardiogram changes in predicting mortality after CO poisoning.
Main Methods
- Prospective cohort study involving 230 adult patients with moderate to severe CO poisoning.
- Patients received hyperbaric oxygen therapy and were followed for up to 11.8 years.
- Myocardial injury defined by elevated cardiac biomarkers or ECG abnormalities; all-cause mortality was the primary outcome.
Main Results
- Myocardial injury was present in 37% of patients (85/230).
- Overall mortality was 24% (54/230) during a median follow-up of 7.6 years.
- Patients with myocardial injury had a significantly higher mortality rate (38% vs. 15%) with an adjusted hazard ratio of 2.1 (95% CI, 1.2-3.7).
Conclusions
- Myocardial injury is a frequent occurrence in hospitalized CO poisoning patients.
- Myocardial injury is a significant independent predictor of long-term mortality.
- This highlights the importance of cardiac monitoring in CO poisoning survivors.