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Updated: Jul 12, 2026

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)
Published on: February 22, 2011
Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS
F Kimura1, C Fujimura, S Ishida
1Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Osaka, Japan. in1110@poh.osaka-med.ac.jp
Abstract:
The authors calculated the progression rate (DeltaFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the DeltaFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the DeltaFS provides an additional predictive index beyond ALSFRS-R alone.
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