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Updated: Aug 13, 2026

Sample Drift Correction Following 4D Confocal Time-lapse Imaging
Published on: April 12, 2014
Stochastic methods for joint registration, restoration, and interpolation of multiple undersampled images
Nathan A Woods1, Nikolas P Galatsanos, Aggelos K Katsaggelos
1Binary Machines, Inc., Schaumburg, IL 60173, USA. nathan@binarymachinesinc.com
Abstract:
Using a stochastic framework, we propose two algorithms for the problem of obtaining a single high-resolution image from multiple noisy, blurred, and undersampled images. The first is based on a Bayesian formulation that is implemented via the expectation maximization algorithm. The second is based on a maximum a posteriori formulation. In both of our formulations, the registration, noise, and image statistics are treated as unknown parameters. These unknown parameters and the high-resolution image are estimated jointly based on the available observations. We present an efficient implementation of these algorithms in the frequency domain that allows their application to large images. Simulations are presented that test and compare the proposed algorithms.
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