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Updated: Aug 13, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[Factor VIII hyperactivity: an arterio-venous thrombogenic factor. Case report]
S L Bennani1, B Vaquette, D Pavin
1Département de cardiologie et maladies vasculaires, Centre cardio-pneumologique niveau 6, hôpital Pontchaillou, CHU, 35033 Rennes.
Archives Des Maladies Du Coeur Et Des Vaisseaux
|January 27, 2006
Summary
Factor VIII hyperactivity is a risk factor for thrombosis, particularly in coronary artery disease. This case highlights the understudied pro-thrombotic role of factor VIII in patients with a history of thrombotic events.
Area of Science:
- Vascular pathology and thrombosis research.
Background:
- Thrombosis is a key factor in cerebral, coronary, and peripheral vascular diseases.
- Coagulation factors play a critical role in atherothrombotic lesion development.
- Elevated pro-coagulant factors increase thrombosis risk.
Observation:
- Factor VIII, a pro-coagulant factor, has been minimally studied for its thrombogenic potential.
- A 62-year-old patient with a history of arterial and venous thromboses presented with myocardial infarction.
- Factor VIII hyperactivity was identified in this patient post-myocardial infarction.
Findings:
- This case demonstrates a link between factor VIII complex hyperactivity and thrombosis.
- Factor VIII hyperactivity was associated with recurrent arterial and venous thrombotic episodes.
- The patient's condition suggests a significant role for factor VIII in coronary pathology.
Implications:
- Factor VIII hyperactivity should be considered in patients with unexplained or recurrent thrombosis.
- Further research into factor VIII's pro-thrombotic mechanisms is warranted.
- Understanding factor VIII's role may lead to improved prevention and treatment strategies for thrombotic diseases, especially coronary artery disease.
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