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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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[Factor VIII hyperactivity: an arterio-venous thrombogenic factor. Case report]

S L Bennani1, B Vaquette, D Pavin

  • 1Département de cardiologie et maladies vasculaires, Centre cardio-pneumologique niveau 6, hôpital Pontchaillou, CHU, 35033 Rennes.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|January 27, 2006
PubMed

Thrombosis is the principal mechanism in vascular pathology, whether cerebral, coronary or peripheral. During the initial stages of infarction, coagulation contributes to vascular occlusion, the haemostatic factors playing a determining role in the development of atherothrombotic lesions. An increase in a coagulation protein, besides any lowering of anticoagulation protein levels, is a risk factor for thrombosis. Among these pro-coagulant factors, the pro-thrombogenic action of factor VIII has without doubt been studied the least. We report the case of a 62 year old patient with a personal and family history of many previous thrombotic episodes, both arterial and venous, in whom factor VIII hyperactivity was discovered after a myocardial infarction. This case underlines the association of the factor VIII complex with thrombosis, and its clinical repercussions, especially the incidence of coronary pathology.

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