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Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions
Jasmina Nikodinovic1, Jennifer M Dinges, Stephen C Bergmeier
1Department of Chemistry, University of Montana, Missoula, Montana 59812, USA.
Abstract:
[reaction: see text]. An efficient resolution of methyl nonactate is reported by biotransformation in shake flask cultures of Rhodococcus erythropolis. The equilibrium of the reaction redox system can be manipulated by switching from aerobic to anaerobic growth, thereby generating both enantiomers of the target in excellent yield and enantiomeric purity.
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