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Updated: Aug 13, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
A new method for recycling asymmetric catalysts via formation of charge transfer complexes
Guillaume Chollet1, Fernand Rodriguez, Emmanuelle Schulz
1Laboratoire de Catalyse Moléculaire, Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris Sud, Bât 420, 91405 Orsay, France.
Abstract:
[reaction: see text]. A new concept for recycling asymmetric bis(oxazoline)-type catalysts is reported. The formation of charge-transfer complexes between the chiral ligand and trinitrofluorenone and their subsequent precipitation and reuse by addition of new substrate solutions is described. The efficiency of this procedure is demonstrated in a Diels-Alder reaction to reach the expected endo product as major isomer (up to 97% de and 94% ee): the catalyst was used up to 12 times without loss of either activity or selectivity.
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