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Genital Paget's disease in a man

Walter Krause1, Andreas Krisp, Stefan Hörster

  • 1Department of Andrology and Venerology, University Hospital, Philipp University, Deutschhausstr. 9, D-35033 Marburg, Germany. krause@med.uni-marburg.de

European Journal of Dermatology : EJD
|January 27, 2006
PubMed

Insights

Extramammary Paget's disease (EMPD) is a rare intraepidermal malignancy. Early diagnosis and considering non-surgical options for noninvasive EMPD can lead to good long-term survival.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Extramammary Paget's disease (EMPD) is a rare intraepidermal malignancy characterized by the proliferation of Pagetoid cells.
  • Pagetoid cells are large intraepidermal cells with distinct morphological features.

Observation:

  • A 67-year-old male presented with a long-standing pruritic scrotal lesion treated initially with anti-inflammatory ointments.
  • A biopsy performed a decade after initial presentation confirmed the diagnosis of extramammary Paget's disease (EMPD).

Findings:

  • Histopathological evaluation revealed EMPD, originating from primary malignant cells of epidermal origin.
  • While EMPD is typically slow-progressing, invasive and metastatic potential exists.

Implications:

  • Nonsurgical treatment modalities should be considered for noninvasive EMPD, given the generally good prognosis and potential for long-term survival.
  • This case highlights the importance of timely biopsy for accurate diagnosis and appropriate management of suspected EMPD.

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