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Updated: Aug 11, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage: a pilot study
J A Frontera1, T Rundek, J M Schmidt
1Division of Stroke and Neurocritical Care, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Abstract:
The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO2R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO2R and in none of 6 patients with preserved reactivity (p = 0.011). Abnormal CO2R preceded the onset of vasospasm in 7 of 9 patients. Abnormal standard TCD testing was not associated with vasospasm.
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