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Related Experiment Videos

Assisted hatching on assisted conception (IVF & ICSI).

M M W Seif1, E C O Edi-Osagie, C Farquhar

  • 1University of Manchester @ St Mary's Hospital, Academic Unit of Obstetrics, Gynaecology & Reproductive Health, Whitworth Park, Manchester, UK, M13 0JH. mwseif@manchester.ac.uk

The Cochrane Database of Systematic Reviews
|January 27, 2006
PubMed
Summary
This summary is machine-generated.

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Assisted hatching (AH) may increase clinical pregnancy rates but does not significantly improve live birth rates. The procedure raises concerns about increased multiple pregnancies, and more research is needed to confirm its benefits and safety.

Area of Science:

  • Reproductive Medicine
  • Infertility Treatments
  • Embryology

Background:

  • Embryo hatching difficulties can impede implantation and conception.
  • In vitro fertilization (IVF) culture conditions and maternal age can affect the zona pellucida, hindering embryo hatching.
  • Assisted hatching (AH) is a technique to aid embryo hatching and improve IVF success rates.

Purpose of the Study:

  • To evaluate the efficacy of assisted hatching (AH) in facilitating live births and clinical pregnancies.
  • To assess the impact of AH on negative pregnancy outcomes, including multiple pregnancies and miscarriage.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted.
  • Searches included major databases like Cochrane, MEDLINE, and EMBASE up to June 2005.

Related Experiment Videos

  • Twenty-three RCTs involving 2668 women were analyzed for pregnancy outcomes.

    • Main Results:

    • Assisted hatching (AH) significantly increased clinical pregnancy rates (OR 1.33, 95% CI 1.12 to 1.57).
    • No significant difference was observed in live birth rates between AH and control groups (OR 1.19, 95% CI 0.81 to 1.73).
    • Multiple pregnancy rates were significantly higher in women undergoing AH (OR 1.83, 95% CI 1.19 to 2.83).

    Conclusions:

    • While AH improves clinical pregnancy rates, evidence for increased live birth rates remains insufficient.
    • The elevated risk of multiple pregnancies with AH requires careful consideration, potentially mitigated by single embryo transfer policies.
    • Current evidence does not support a general recommendation for assisted hatching.