Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Mucosal immune dysfunction associated with alcoholic IgA nephropathy.

S M Smith¹, S Tokuda, H Tsukamoto

¹University of New Mexico, School of Medicine, Department of Pathology, Albuquerque.

Clinical Immunology and Immunopathology

|September 1, 1992

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of risk factors for nephrotoxicity associated with high-dose vancomycin in Japanese patients.

Die Pharmazie·2021

Same author

Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1.

Cancer gene therapy·2016

Same author

Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus-the 'D-shuttle' project.

Journal of radiological protection : official journal of the Society for Radiological Protection·2015

Same author

ISOLATION AND IDENTIFICATION OF 2-ACETAMIDO-1-β-(L-β-ASPARTAMIDO)-1,2-DIDEOXY-D-GLUCOSE FROM PARTIAL HYDROLYSATE OF OVALBUMIN GLYCOPEPTIDE PREPARATION.

Biochemical and biophysical research communications·2015

Same author

Evaluation of the extent of ground-glass opacity on high-resolution CT in patients with interstitial pneumonia associated with systemic sclerosis: comparison between quantitative and qualitative analysis.

Clinical radiology·2014

Same author

Behçet's disease associated with complement component 9 (C9) deficiency.

Modern rheumatology·2014

Same journal

Mechanisms of virus replication, persistence, and regulation of immune responses.

Clinical immunology and immunopathology·2020

Same journal

Cumulative subject index for volumes 86-89

Clinical immunology and immunopathology·1998

Same journal

D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease.

Clinical immunology and immunopathology·1998

Same journal

Characterization of gastric Na+/I- symporter of the rat.

Clinical immunology and immunopathology·1998

Same journal

CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.

Clinical immunology and immunopathology·1998

Same journal

Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus.

Clinical immunology and immunopathology·1998

See all related articles

Chronic alcohol consumption may lead to IgA nephropathy (IAN) by altering the immune system. Studies show alcoholics with IAN have increased serum IgA and changes in intestinal immune cells.

Area of Science:

Immunology
Nephrology
Gastroenterology

Background:

IgA nephropathy (IAN) is a kidney disease characterized by IgA deposition in the glomeruli.
The role of chronic alcohol consumption in the pathogenesis of IAN is not fully understood.

Purpose of the Study:

To investigate the hypothesis that alcohol-induced immune system alterations contribute to the development of IgA nephropathy.

Main Methods:

Wistar rats were administered an alcohol-containing liquid diet, while control rats received an isocaloric glucose diet.
Immunohistochemistry was used to diagnose IgA nephropathy by detecting mesangial IgA deposition.
Lymphocyte populations in the intestinal lamina propria and spleen were analyzed.

Main Results:

Related Experiment Videos

Alcoholic rats with IAN exhibited a fourfold increase in serum IgA compared to controls.
Alcoholic rats without IAN showed a twofold increase in serum IgA.
A significant decrease in overall lymphocytes was observed in the intestinal lamina propria of alcoholic rats, with a relative increase in IgA-B cells in those with IAN.

Conclusions:

Chronic alcohol consumption may induce IgA nephropathy through the dysfunction of the mucosal immune system.
Alterations in intestinal lymphocyte populations, particularly IgA-B cells, may play a role in alcohol-related IAN development.