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[Gastrointestinal stromal tumors]

C Eccher1, R Famà, G Berlanda

  • 1UO Chirurgia 2a, Ospedale Santa Chiara, Trento.

I Supplementi Di Tumori : Official Journal of Societa Italiana Di Cancerologia ... [Et Al.]
|January 28, 2006
PubMed

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...