Related Experiment Video
Updated: Aug 13, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Synthesis and application of negatively charged PNA analogues
Vladimir A Efimov1, Oksana G Chakhmakhcheva, Eric Wickstrom
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. eva@mail.ibch.ru
Abstract:
Negatively charged DNA mimics containing phosphonate analogoues of peptide nucleic acids were designed, and their physicochemical and biological properties were evaluated in the comparison with natural oligonucleotides, classical peptide nucleic acids, and morpholino phosphorodiamidate oligonucleotide analogues. The results obtained revealed a high potential of phosphonate-containing PNA derivatives for a number of biological applications, such as diagnostic, nucleic acids analysis, and inhibition of gene expression.
Related Concept Videos
Diazonium Group Substitution: –OH and –H
Anionic Chain-Growth Polymerization: Overview
ATP and Macromolecule Synthesis
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
2° Amines to N-Nitrosamines: Reaction with NaNO2
Other Nuclides: 31P, 19F, 15N NMR
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a high...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

