Confocal microscopy studies of a model oligoribonucleotide HIV inhibitor
Robyn M Hyde1, Keith Jensen, Jindrich Kopecek
1Westminster College, Salt Lake City, Utah, USA.
Nucleosides, Nucleotides & Nucleic Acids
|January 28, 2006
Abstract:
Previous work has shown that novel amphipalhic oligo and polyribonucleotides are potent inhibitors of HIV. It was hypothesized that the mechanism(s) of action for these compounds might be inhibition of retroviral reverse transcriptase (RT) and/or viral uptake by cells. A fluorescent oligonucleotide analog was prepared, and confocal microscopy studies were undertaken in order to examine oligonucleotide-cell interactions.


