Related Experiment Video
Updated: Aug 13, 2026
A Conflict Model of Reward-seeking Behavior in Male Rats
Published on: February 20, 2019
Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats
Julia O Fedotova1, G Hartmann, L Lénárd
1SV Anichkov Department of Neuropharmacology, Institute of Experimental Medicine of the Russian Academy of Medical Sciences, St Petersburg, Russia. julia.fedotova@mail.ru
Abstract:
The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17beta-estradiol (0.5 microg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-HT1A receptor antagonist NAN-190 alone significantly improved PAR (p<0.05) in intact females with proestrus and estrus and in OVX females. Administration of 5-HT1A receptor agonist 8-OH-DPAT alone or in combination with 17beta-estradiol significantly (p<0.05) improved PAR in OVX rats and failed to normalize PAR in intact rats with proestrus and estrus. Results of the work specify the involvement of 5-HT1A receptors in the mechanisms of passive avoidance learning in OVX female rats.
