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[Antilactoferrin activity of microorganisms].

O V Bukharin, O L Kartashova, S B Kirgizova

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 28, 2006
    PubMed
    Summary
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    The antilactoferrin sign was detected in various microbes from patients with inflammatory diseases. Its presence and activity were higher in women with vaginal and cervical inflammation compared to healthy individuals.

    Area of Science:

    • Microbiology
    • Immunology
    • Human Health

    Background:

    • Microbial infections and dysbacteriosis are linked to inflammatory conditions.
    • Lactoferrin plays a role in innate immunity.
    • Antilactoferrin activity in microbes may impact host-pathogen interactions.

    Purpose of the Study:

    • To analyze the prevalence and manifestation of the antilactoferrin sign in microbial strains from patients with inflammatory diseases and intestinal dysbacteriosis.
    • To compare antilactoferrin activity in microflora from patients versus healthy individuals.
    • To investigate the relationship between antilactoferrin activity and lactoferrin levels during inflammation.

    Main Methods:

    • Analysis of 165 microbial strains (e.g., Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans) from various human biotopes.

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  • Quantification of antilactoferrin sign detection rate and manifestation level.
  • Comparison of microbial activity between patient groups and healthy controls.
  • Assessment of the correlation between microflora antilactoferrin activity and host lactoferrin content.

    • Main Results:

    • High detection rates of antilactoferrin activity were observed across different microbial species (E. coli: 43-90%, S. aureus: 20-86%, K. pneumoniae: 60-100%, C. albicans: 76-78%).
    • The sign was most frequent and pronounced in strains from the female reproductive tract.
    • Antilactoferrin activity was significantly higher in vaginal and cervical microflora of patients compared to healthy individuals.
    • An inverse relationship was found between microflora antilactoferrin activity and lactoferrin content during inflammation in women.

    Conclusions:

    • The antilactoferrin sign is prevalent in clinically relevant microbes, particularly in the female reproductive tract.
    • Increased antilactoferrin activity in microflora correlates with inflammatory conditions and reduced host lactoferrin.
    • This finding suggests a potential role for microbial antilactoferrin activity in the pathogenesis of inflammatory diseases and dysbiosis.