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Updated: May 28, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Methylglyoxal comes of AGE
Ravichandran Ramasamy1, Shi Fang Yan, Ann Marie Schmidt
1Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Abstract:
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.
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