Related Experiment Video
Updated: Aug 13, 2026

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
Published on: November 11, 2022
The role of growth hormone in neural development
Arjan Scheepens1, Tanja A E Möderscheim, Peter D Gluckman
1Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand. a.scheepens@auckland.ac.nz
Abstract:
Growth hormone (GH) is integrally involved in the development of the central nervous system (CNS), as well as during its recovery from injury, two processes that share many similarities and may influence CNS functionality. This review discusses some of the most recent findings in the field and, in particular, the ontogeny, distribution, regulation and putative functions of GH and its receptor within the CNS, particularly during development. The relative roles of peripheral GH, acting in part through insulin-like growth factor-I, and of the autocrine/paracrine GH system within the brain are considered. The potential role of GH as a therapeutic agent to influence brain development and function is discussed.
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Nature and Nurture
Neurulation
Hormones of the Pituitary Gland
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Neurotransmitters

